https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Toll-like receptor 7 governs interferon and inflammatory responses to rhinovirus and is suppressed by IL-5-induced lung eosinophilia https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22168 -/-) BALB/c mice were intranasally sensitised and challenged with HDM prior to infection with RV1B. In some experiments, mice were administered recombinant IFN or adoptively transferred with plasmacytoid dendritic cells (pDC). Results: Allergic Tlr7-/- mice displayed impaired IFN release upon RV1B infection, increased virus replication and exaggerated eosinophilic inflammation and airways hyper reactivity. Treatment with exogenous IFN or adoptive transfer of TLR7-competent pDCs blocked these exaggerated inflammatory responses and boosted IFNγ release in the absence of host TLR7 signalling. TLR7 expression in the lungs was suppressed by allergic inflammation and by interleukin (IL)-5-induced eosinophilia in the absence of allergy. Subjects with moderate-to-severe asthma and eosinophilic but not neutrophilic airways inflammation, despite inhaled steroids, showed reduced TLR7 and IFNλ2/3 expression in endobronchial biopsies. Furthermore, TLR7 expression inversely correlated with percentage of sputum eosinophils. Conclusions: This implicates IL-5-induced airways eosinophilia as a negative regulator of TLR7 expression and antiviral responses, which provides a molecular mechanism underpinning the effect of eosinophil-targeting treatments for the prevention of asthma exacerbations.]]> Wed 11 Apr 2018 15:36:21 AEST ]]> Versican V1 overexpression induces a myofibroblast-like phenotype in cultured fibroblasts https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:26972 Wed 11 Apr 2018 09:17:19 AEST ]]> TLR2-mediated innate immune priming boosts lung anti-viral immunity https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48671 Tue 28 Mar 2023 10:25:49 AEDT ]]> The fibrogenic actions of the coagulant and plasminogen activation systems in pulmonary fibrosis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47646 Tue 24 Jan 2023 14:51:39 AEDT ]]> TLR7 agonist loaded airway epithelial targeting nanoparticles stimulate innate immunity and suppress viral replication in human bronchial epithelial cells https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47015 Tue 13 Dec 2022 11:55:35 AEDT ]]> An approach to measuring and encouraging research translation and research impact https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24213 Thu 09 Dec 2021 10:12:04 AEDT ]]> An approach to measuring and encouraging research translation and research impact https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30192 Thu 09 Dec 2021 10:11:43 AEDT ]]> Annexin A2 contributes to lung injury and fibrosis by augmenting factor Xa fibrogenic activity https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34569 Thu 04 Nov 2021 10:38:24 AEDT ]]> PM10-stimulated airway epithelial cells activate primary human dendritic cells independent of uric acid: application of an in vitro model system exposing dendritic cells to airway epithelial cell-conditioned media https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19679 Sat 24 Mar 2018 07:53:38 AEDT ]]> Urban particulate matter increases human airway epithelial cell IL-1β secretion following scratch wounding and H1N1 influenza A exposure in vitro https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27531 Sat 24 Mar 2018 07:28:58 AEDT ]]> Pharmacological HIF-1 stabilization promotes intestinal epithelial healing through regulation of α-integrin expression and function https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49107 Fri 05 May 2023 11:32:08 AEST ]]>